Synthesis, and phytopathological application of some novel amino acid, dipeptide and diphenylphosphonic acid derivatives of 2-aminopyrimidine
نویسندگان
چکیده
A new series of 2-[N-(Tosor Pht-)aminoacylp-substituted phenylmethyleneamino]pyrimdines (V-XII) was synthesized via the reaction of Schiff bases, 2-(4-substituted benzylidene)aminopyrimdines (I,II) with the requisite tosyl or phthalylaminoacyl chlorides. Elongation of these amino acid derivatives to form the corresponding dipeptides (XVII-XXIV) were synthesized starting with 2-[glycyl or Dl-valylp-substituted phenylmethyleneamino]pyrimdines (XIII-XVI). Diphenylphosphonic acid ester derivatives (III,IV) also be synthesized. All the prepared compounds were characterized by elemental analyses, IR, HNMR and mass spectral studies. The resulting novel amino acid derivatives were screened for their (In Vitro) antimicrobial activity against Gram-positive and negative bacteria as well as for their antifungal activity and (In Vivo) application against plant pathogenic fungus Botrytis cinerea , the causal agent of cucumber plant (Cucmis. sativa L) gray mold disease.
منابع مشابه
Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives
A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against ADP and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. None of the compounds showed satisfactory activity against the aggregation induced by ADP. However, satisfac...
متن کاملSynthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives
A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against ADP and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. None of the compounds showed satisfactory activity against the aggregation induced by ADP. However, satisfac...
متن کاملSynthesis and radioprotective study of novel amino-alkyldithiocarbamic acid derivatives against γ-irradiation in mice
Background: The aim of this study was to evaluate the radioprotective capacity of some novel aminoalkylated dithiocarbamic acid potassium salts against γ-irradiation in mice. Materials and Methods: Eight compounds containing 2-aminoethyl-, 3- aminopropyl-, 4-aminobutyl-, 5-aminopentyl-, 6- aminohexyl-, 7-aminoheptyl-, 8-aminooctyl and 9- aminononyl of dithiocarbamate derivatives were prepared. ...
متن کاملApplication of Nicotinic Acid Functionalized Chlorosulfonic Acid as a Green Catalyst for the Synthesis of Bis(2-methyl-1Hindole)Derivatives
3-Carboxy-1-sulfopyridin-1-ium chloride ([CPySO3H]+Cl-) as a novel ionic organocatalyst for thecondensation of aldehydes and 2-methylindole to synthesize bis(2-methyl-1H-indole) derivatives inacetonitrile at room temperature has been developed. Some tetrakis (2-methyl-1H-indole)derivatives have also been synthesized by the reaction of 2,2'-(butane-1,4-diylbis(oxy))dibenzaldehyde and 2-methylind...
متن کاملElectron as potential and green catalyst in the multicomponent synthesis of pyrano [2, 3-d] pyrimidine derivatives
An electroorganic reaction for the synthesis of 7-amino-2, 4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-pyrano[2, 3-d] pyrimidine-6-carbonitrile and ethyl-7-amino-2, 4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-pyrano[2, 3-d] pyrimidine-6-carboxylate derivatives are described, using an electrogenerated base of the anion of malonitrile or ethylcyanoacetate. This one-pot, three-component condensation of an a...
متن کامل